Article
Genetic Screens for Determination of Mechanism of Action.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016
Gay-Andrieu Françoise, Alex Deepu, Calderone Richard
Abstract excerpt
The search for new antifungal drugs and cell targets continues. During the discovery process, mechanism-of-action (MOA) studies are critical to the continued progress of the compound through the pipeline. There are many approaches that can be utilized in understanding the MOA. One of these approaches is a genetic screen utilizing the availability of Saccharomyces cerevisiae mutant libraries. Both null and...
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