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Article

Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2008

Mayr Johannes A, Meierhofer David, Zimmermann Franz, Feichtinger Rene, Kögler Christian, Ratschek Manfred, Schmeller Nikolaus, Sperl Wolfgang, Kofler Barbara

Abstract excerpt

PURPOSE: Many solid tumors exhibit abnormal aerobic metabolism characterized by increased glycolytic capacity and decreased cellular respiration. Recently, mutations in the nuclear encoded mitochondrial enzymes fumarate hydratase and succinate dehydrogenase have been identified in certain tumor types, thus demonstrating a direct link between mitochondrial energy metabolism and tumorigenesis. Although mutations in...

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Identifiers

PMID: 18413815
DOI: 10.1158/1078-0432.CCR-07-4131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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