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Mitochondrial respiratory complex II is altered in renal carcinoma.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2025

Miklovicova Sona, Volpini Luca, Sanovec Ondrej, Monaco Federica, Vanova Katerina Hadrava, Novak Jaromir, Boukalova Stepana, Zobalova Renata, Klezl Petr, Tomasetti Marco, Bobek Vladimir, Fiala Vojtech, Vcelak Josef, Santarelli Lory, Bielcikova Zuzana, Komrskova Katerina, Kolostova Katarina, Pacak Karel, Dvorakova Sarka, Neuzil Jiri

Abstract excerpt

BACKGROUND: Renal cell carcinoma (RCC) is a disease typified by anomalies in cell metabolism. The function of mitochondria, including subunits of mitochondrial respiratory complex II (CII), in particular SDHB, are often affected. Here we investigated the state and function of CII in RCC patients. METHODS: We evaluated tumour tissue as well as the adjacent healthy kidney tissue of 78 patients with RCC of different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39486656
DOI: 10.1016/j.bbadis.2024.167556

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