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Article

Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dubé tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2015

Lang Martin, Vocke Cathy D, Merino Maria J, Schmidt Laura S, Linehan W Marston

Abstract excerpt

Oncocytomas are mostly benign tumors characterized by accumulation of defective mitochondria, and in sporadic cases, are associated with disruptive mitochondrial DNA (mtDNA) mutations. However, the role mtDNA mutations have in renal tumors of Birt-Hogg-Dubé (BHD) patients and other renal oncocytomas with an apparent genetic component has not been investigated to date. Here we characterize the mitochondrial genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26428318
DOI: 10.1038/modpathol.2015.101
PMCID: PMC4628590

Genes

BMF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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