Article
Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma.
Carcinogenesis - 1 May 2002
Simonnet Hélène, Alazard Nathalie, Pfeiffer Kathy, Gallou Catherine, Béroud Christophe, Demont Jocelyne, Bouvier Raymonde, Schägger Hermann, Godinot Catherine
Abstract excerpt
A mechanism decreasing oxidative metabolism during normal cell division and growth is expected to direct substrates toward biosyntheses rather than toward complete oxidation to CO(2). Hence, any event decreasing oxidative phosphorylations (OXPHOS) could provide a proliferating advantage to a transformed or tumor cell in an oxidative tissue. To test this hypothesis, we studied mitochondrial enzymes, DNA and OXPHOS...
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