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Article

Gender-Related Survival Differences Associated with<i>EGFR</i>Polymorphisms in Metastatic Colon Cancer

15 Apr 2008

Abstract excerpt

Evidence is accumulating supporting gender-related differences in the development of colonic carcinomas. Sex steroid hormone receptors are expressed in the colon and interact with epidermal growth factor receptor (EGFR), a gene widely expressed in colonic tissue. Increased EGFR expression is linked with poor prognosis in colon cancer. Within the EGFR gene there are two functional polymorphisms of interest: a...

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PMID: 18413774
DOI: 10.1158/0008-5472.can-07-2718

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