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Article

Influence of thymidylate synthase DNA polymorphisms and gender on the clinical evolution of patients with advanced colorectal cancer.

Oncology reports - 1 May 2010

Fernández-Contreras Maria-Encarnación, Sánchez-Hernández José Javier, Guijarro Mercedes, Gisbert Javier P, Rivas Noa, García de Paredes María-Luisa, Hinojar-Gutiérrez Adolfo, Gamallo Carlos

Abstract excerpt

Experimental evidence has revealed that several thymidylate synthase (TS) DNA polymorphisms modulate gene expression, which, in turn is known to be down-regulated by oestrogen receptor subtypes. Consequently, this process might be influenced by female hormones. Based on these data, we investigated whether patient's gender and TS polymorphism exert an interactive effect on the clinical evolution of patients with...

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Identifiers

PMID: 20372856
DOI: 10.3892/or_00000776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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