The EGFR R521K polymorphism influences the risk to develop colorectal cancer.

doi:10.3233/DMA-2011-0826

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Article

The EGFR R521K polymorphism influences the risk to develop colorectal cancer.

Cancer biomarkers : section A of Disease markers - 1 Jan 2010

Martinelli Marcella, Ugolini Giampaolo, Scapoli Luca, Rivetti Stefano, Lauriola Mattia, Mattei Gabriella, Rosati Giancarlo, Montroni Isacco, Manaresi Alessio, Zattoni Davide, Taffurelli Mario, Solmi Rossella

Abstract excerpt

Epidermal growth factor receptor (EGFR) family members (EGFR, HER2, HER3 and HER4) have been extensively investigated for its possible involvement in cancer development and progression. In colorectal cancer (CRC) EGFR family has been found frequently over-expressed, thus therapy targeting EGFR has been developed. Interestingly, it has been observed that genetic variants in these receptors may alter the...

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PMID: 21896992
DOI: 10.3233/DMA-2011-0826
PMCID: PMC13015851

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EGFR

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