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Article

Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2007

Zhang Wu, Press Oliver A, Haiman Christopher A, Yang Dong Yun, Gordon Michael A, Fazzone William, El-Khoueiry Anthony, Iqbal Syma, Sherrod Andy E, Lurje Georg, Lenz Heinz-Josef

Abstract excerpt

PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate levels, which affects DNA synthesis and methylation. Two MTHFR gene polymorphisms, C677T and A1298C, are linked to altered enzyme activity. Several studies have shown these two polymorphisms to be associated with response to fluorouracil (FU) -based treatment in advanced colon cancer patients, but data are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17704422
DOI: 10.1200/JCO.2007.11.4710

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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