Article
Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis.
Arthritis research & therapy - 7 Mar 2017
Gentil Coline A, Gammill Hilary S, Luu Christine T, Mayes Maureen D, Furst Dan E, Nelson J Lee
Abstract excerpt
BACKGROUND: Specific HLA class II alleles are associated with systemic sclerosis (SSc) risk, clinical characteristics, and autoantibodies. HLA nomenclature initially developed with antibodies as typing reagents defining DRB1 allele groups. However, alleles from different DRB1 allele groups encode the same third hypervariable region (3rd HVR) sequence, the primary T-cell recognition site, and 3rd HVR charge...
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