Article
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia.
Annals of neurology - 1 Jun 2008
Mesulam Marsel, Wicklund Alissa, Johnson Nancy, Rogalski Emily, Léger Gabriel C, Rademaker Alfred, Weintraub Sandra, Bigio Eileen H
Abstract excerpt
OBJECTIVE: To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD pathology is atypically distributed to fit the aphasic phenotype. METHODS: Neuropsychological and neuropathological analyses of 23 consecutive PPA autopsies. All had qualitative determination of neurofibrillary tangle (NFT) density....
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