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Article

Progranulin-associated PiB-negative logopenic primary progressive aphasia.

Journal of neurology - 1 Mar 2014

Josephs Keith A, Duffy Joseph R, Strand Edythe A, Machulda Mary M, Vemuri Prashanthi, Senjem Matthew L, Perkerson Ralph B, Baker Matthew C, Lowe Val, Jack Clifford R, Rademakers Rosa, Whitwell Jennifer L

Abstract excerpt

The logopenic variant of primary progressive aphasia (lvPPA) strongly associates with Alzheimer's disease, but can also associate with frontotemporal lobar degeneration. We aimed to assess the frequency of lvPPA in patients with speech and language disorders without β-amyloid deposition, and to perform detailed neuroimaging and genetic testing in such lvPPA patients. Seventy-six patients with a neurodegenerative...

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PMID: 24449064
DOI: 10.1007/s00415-014-7243-9
PMCID: PMC3961471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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