Article
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
Acta neuropathologica - 1 Jul 2010
Bigio Eileen H, Mishra Manjari, Hatanpaa Kimmo J, White Charles L, Johnson Nancy, Rademaker Alfred, Weitner Bing Bing, Deng Han-Xiang, Dubner Steven D, Weintraub Sandra, Mesulam Marsel
Abstract excerpt
The clinical syndrome of primary progressive aphasia (PPA) can be associated with a variety of neuropathologic diagnoses at autopsy. Thirty percent of cases have Alzheimer disease (AD) pathology, most often in the usual distribution, which defies principles of brain-behavior organization, in that aphasia is not symptomatic of limbic disease. The present study investigated whether concomitant TDP-43 pathology...
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