Article
Alzheimer disease without neocortical neurofibrillary tangles: "a second look".
Neurology - 13 Apr 2004
Tiraboschi P, Sabbagh M N, Hansen L A, Salmon D P, Merdes A, Gamst A, Masliah E, Alford M, Thal L J, Corey-Bloom J
Abstract excerpt
OBJECTIVE: To compare the clinical and pathologic features of plaque only Alzheimer disease (POAD) with plaque and tangle Alzheimer disease (PTAD). METHODS: An autopsy series of 16 patients with POAD and 32 subjects with PTAD on whom extensive antemortem neuropsychological testing was available. Plaques, tangles, and cerebral amyloid angiopathy were examined in the neocortex and hippocampus using thioflavin S...
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