Article
Detection of HBV core promoter and precore mutations helps distinguish flares of chronic hepatitis from acute hepatitis B.
Journal of gastroenterology and hepatology - 1 May 2008
Kusumoto Koichiro, Yatsuhashi Hiroshi, Nakao Rumiko, Hamada Rumiko, Fukuda Mika, Tamada Yoko, Taura Naota, Komori Atsumasa, Daikoku Manabu, Hamasaki Keisuke, Nakao Kazuhiko, Ishibashi Hiromi, Miyakawa Yuzo, Eguchi Katsumi
Abstract excerpt
BACKGROUND AND AIM: Acute exacerbation of chronic hepatitis B has to be distinguished from acute hepatitis, because treatment strategies differ between them. METHODS: Mutations in the core promoter and precore region of hepatitis B virus (HBV) were determined in 36 patients with acute exacerbation of chronic hepatitis B, in whom alanine aminotransferase (ALT) increased above 500 IU/L, as well as the 36 patients...
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