Different precore/core mutations of hepatitis B interact with, limit, or favor liver fibrosis severity.

doi:10.1111/jgh.13338

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Article

Different precore/core mutations of hepatitis B interact with, limit, or favor liver fibrosis severity.

Journal of gastroenterology and hepatology - 1 Oct 2016

Ducancelle Alexandra, Pivert Adeline, Bertrais Sandrine, Boursier Jérôme, Balan Viorica, Veillon Pascal, le Guillou-Guillemette Hélène, Thibault Vincent, Castelain Sandrine, Roquebert Bénédicte, Coste-Burel Marianne, Mackiewicz Vincent, Schvoerer Evelyne, Larrat Sylvie, Maylin Sarah, Alain Sophie, Loustaud-Ratti Véronique, Gordien Emmanuel, Gozlan Joël, Brodard Véronique, Chevaliez Stéphane, Calès Paul, Lunel-Fabiani Françoise

Abstract excerpt

BACKGROUND AND AIM: The impact of basal core promoter (BCP) and precore (PC) mutants of the hepatitis B virus (HBV) on liver disease severity remains controversial. The aim of the present study was to screen BCP and PC mutations in 252 HBV surface antigen (HBsAg) positive carriers in France and to assess relationships between these mutations and severe fibrosis. METHODS: Direct sequencing of the precore/core gene...

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PMID: 26992056
DOI: 10.1111/jgh.13338

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