Article
Viral escape from the neutralizing antibody response: the lymphocytic choriomeningitis virus model.
Immunogenetics - 1 Apr 2001
Ciurea A, Hunziker L, Zinkernagel R M, Hengartner H
Abstract excerpt
In addition to CD8+ cytotoxic T lymphocyte (CTL) responses, neutralizing antibodies contribute substantially to the long-term immune control of noncytopathic viruses, as demonstrated during infection with the lymphocytic choriomeningitis virus (LCMV). The high virus load during the initial phase of an infection and the ability of this RNA virus to spontaneously acquire mutations are important prerequisites for...
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