Article
A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome.
Journal of virology - 1 Dec 1996
Teng M N, Borrow P, Oldstone M B, de la Torre J C
Abstract excerpt
Persistent infection of C3H/St mice with certain strains of lymphocytic choriomeningitis virus (LCMV) causes a growth hormone (GH) deficiency syndrome (GHDS) manifested as growth retardation and hypoglycemia. Infected mice show high levels of viral replication in the GH-producing cells in the ant...
Topics
- Animals
- Cell Line
- Cricetinae
- Genetic Variation
- Glycoproteins
- Growth Disorders
- Hypoglycemia
- Lymphocytic choriomeningitis virus
- Mice
- Mice, Inbred C3H
- Phenylalanine
- Reassortant Viruses
- Serine
- Syndrome
- Viral Proteins