Article
Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene.
Annals of the rheumatic diseases - 1 Mar 2021
Boer Cindy Germaine, Yau Michelle S, Rice Sarah J, Coutinho de Almeida Rodrigo, Cheung Kathleen, Styrkarsdottir Unnur, Southam Lorraine, Broer Linda, Wilkinson Jeremy Mark, Uitterlinden André G, Zeggini Eleftheria, Felson David, Loughlin John, Young Mariel, Capellini Terence Dante, Meulenbelt Ingrid, van Meurs Joyce Bj
Abstract excerpt
BACKGROUND: Despite recent advances in the understanding of the genetic architecture of osteoarthritis (OA), only two genetic loci have been identified for OA of the hand, in part explained by the complexity of the different hand joints and heterogeneity of OA pathology. METHODS: We used data from the Rotterdam Study (RSI, RSII and RSIII) to create three hand OA phenotypes based on clustering patterns of...
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