Article
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand.
Arthritis and rheumatism - 1 Jun 2009
Evangelou Evangelos, Chapman Kay, Meulenbelt Ingrid, Karassa Fotini B, Loughlin John, Carr Andrew, Doherty Michael, Doherty Sally, Gómez-Reino Juan J, Gonzalez Antonio, Halldorsson Bjarni V, Hauksson Valdimar B, Hofman Albert, Hart Deborah J, Ikegawa Shiro, Ingvarsson Thorvaldur, Jiang Qing, Jonsdottir Ingileif, Jonsson Helgi, Kerkhof Hanneke J M, Kloppenburg Margreet, Lane Nancy E, Li Jia, Lories Rik J, van Meurs Joyce B J, Näkki Annu, Nevitt Michael C, Rodriguez-Lopez Julio, Shi Dongquan, Slagboom P Eline, Stefansson Kari, Tsezou Aspasia, Wallis Gillian A, Watson Christopher M, Spector Tim D, Uitterlinden Andre G, Valdes Ana M, Ioannidis John P A
Abstract excerpt
OBJECTIVE: GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of the GDF5 gene or the rs7775 and rs288326 polymorphisms of the FRZB gene have been conflicting or inconclusive. To examine these associations, we performed a large-scale meta-analysis of...