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Article

Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis.

American journal of respiratory cell and molecular biology - 1 Sept 2008

Pulichino Anne-Marie, Wang I-Ming, Caron Alexandre, Mortimer James, Auger Anick, Boie Yves, Elias Jack A, Kartono Aileen, Xu Lijing, Menetski Joseph, Sayegh Camil E

Abstract excerpt

Lung fibrosis is characterized by excessive accumulation of extracellular matrix components leading to progressive airflow limitation. Distinct profibrotic pathways converge on the activation of transforming growth factor-beta (TGF-beta), a central growth factor implicated in most fibroproliferative diseases. Recently, enforced expression of bioactive human TGF-beta1 (hTGF-beta1) in lungs of transgenic mice was...

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Identifiers

PMID: 18403781
DOI: 10.1165/rcmb.2007-0186OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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