Article
Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.
American journal of respiratory and critical care medicine - 15 Nov 2001
Zhu Z, Lee C G, Zheng T, Chupp G, Wang J, Homer R J, Noble P W, Hamid Q, Elias J A
Abstract excerpt
Noninflammatory structural alterations, variously referred to as airway remodeling, are well documented in the asthmatic airway. However, the pathogenesis of these alterations, the importance of airway remodeling in generating the asthma phenotype, and the natural history of airway remodeling responses have not been adequately defined. Because exaggerated cytokine production is a characteristic feature of the...
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