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Article

Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis

11 Sept 2019

Abstract excerpt

Transforming growth factor (TGF)-β1, a main profibrogenic cytokine in the progression of idiopathic pulmonary fibrosis (IPF), induces differentiation of pulmonary fibroblasts to myofibroblasts that produce high levels of collagen, leading to concomitantly loss of lung elasticity and function. Recent studies implicate the importance of microRNAs (miRNAs) in IPF but their regulation and individual pathological...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 31511493
DOI: 10.1038/s41419-019-1873-x

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