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Article

Advantages of the high resolution melting in the detection of BRCA1 or BRCA2 mutation carriers.

Clinical biochemistry - 1 Oct 2009

Jiménez Inmaculada de Juan, Esteban Cardeñosa Eva, Palanca Suela Sarai, González Eva Barragán, Bolufer Gilabert Pascual

Abstract excerpt

OBJECTIVE: The aim of the study is to explore the reliability of the high resolution melting (HRM) analysis for the identification of BRCA1/BRCA2 mutation carriers among the family members of index patient (IP) and for distinguishing the presence of two or more genetic variants within the same amplicon. DESIGN AND METHODS: We studied 27 different BRCA1/BRCA2 pathogenic mutations detected in 35 families with 194...

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Source

Identifiers

PMID: 19616529
DOI: 10.1016/j.clinbiochem.2009.07.010

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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