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Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies

10 Apr 2008

Abstract excerpt

The interactions between pathogens and hosts lead to a massive upregulation of antimicrobial host effector molecules. Among these, the 65 kDa guanylate binding proteins (GBPs) are interesting candidates as intricate components of the host effector molecule repertoire. Members of the GBP family are highly conserved in vertebrates. Previous reports indicate an antiviral activity of human GBP1 (hGBP1) and murine...

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PMID: 18402675
DOI: 10.1186/1471-2164-9-158

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