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Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection

3 Jul 2020

Abstract excerpt

Abstract Guanylate binding proteins (GBPs) are important effector molecules of autonomous response induced by proinflammatory stimuli, mainly IFNs. The murine GBPs clustered in chromosome 3 (GBPchr3) contains the majority of human homologous GBPs. Despite intense efforts, mycobacterial-promoted diseases are still a major public health problem. However, the combined importance of GBPchr3 during mycobacterial...

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PMID: 32620042
DOI: 10.1002/jlb.4ma0620-526rr

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