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Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against <i>Toxoplasma gondii</i>

25 Jan 2017

Abstract excerpt

Mesenchymal stromal cells (MSCs) have recently been shown to play important roles in mammalian host defenses against intracellular pathogens, but the molecular mechanism still needs to be clarified. We confirmed that human MSCs (hMSCs) prestimulated with IFN-γ showed a significant and dose-dependent ability to inhibit the growth of two types of Toxoplasma gondii [type I RH strain with green fluorescent proteins...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 28123064
DOI: 10.1073/pnas.1619665114

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