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Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice

7 Feb 2018

Abstract excerpt

Interferon-induced GTPases (guanylate-binding proteins, GBPs) play an important role in inflammasome activation and mediate innate resistance to many intracellular pathogens, but little is known about their role in leishmaniasis. We therefore studied expression of Gbp2b/Gbp1 and Gbp5 mRNA in skin, inguinal lymph nodes, spleen and liver after Leishmania major infection and in uninfected controls. We used two...

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PMID: 29467757
DOI: 10.3389/fimmu.2018.00130

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