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Advances in the management of MEN2: from improved surgical and medical treatment to novel kinase inhibitors

15 Nov 2017

Abstract excerpt

Medullary thyroid carcinoma (MTC), a tumor derived from the neural crest, occurs either sporadically or as the dominant component of the type 2 multiple endocrine neoplasia (MEN) syndromes, MEN2A and MEN2B. The discovery that mutations in the RET protooncogene cause hereditary MTC was of great importance, since it led to the development of novel methods of diagnosis and treatment. For example, the detection of a...

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PMID: 29142004
DOI: 10.1530/erc-17-0325

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