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Article

Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC.

Molecular and cellular endocrinology - 30 Jun 2010

Frank-Raue Karin, Rondot Susanne, Raue Friedhelm

Abstract excerpt

Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the RET proto-oncogene. Three distinct clinical subtypes of MEN 2 have been characterized: MEN 2A, MEN 2B, and familial medullary thyroid carcinoma (FMTC). The specific RET mutation may suggest a predilection toward a particular phenotype and clinical course, with strong...

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Identifiers

PMID: 20083156
DOI: 10.1016/j.mce.2010.01.012

Genes

RET

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