Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease.

Molecular psychiatry - 1 Feb 2024

Kim Su-Jeong, Miller Brendan, Hartel Nicolas G, Ramirez Ricardo, Braniff Regina Gonzalez, Leelaprachakul Naphada, Huang Amy, Wang Yuzhu, Arpawong Thalida Em, Crimmins Eileen M, Wang Penglong, Sun Xianbang, Liu Chunyu, Levy Daniel, Yen Kelvin, Petzinger Giselle M, Graham Nicholas A, Jakowec Michael W, Cohen Pinchas

Abstract excerpt

Mitochondrial DNA single nucleotide polymorphisms (mtSNPs) have been associated with a reduced risk of developing Parkinson's disease (PD), yet the underlying mechanisms remain elusive. In this study, we investigate the functional role of a PD-associated mtSNP that impacts the mitochondrial-derived peptide (MDP) Small Humanin-like Peptide 2 (SHLP2). We identify m.2158 T > C, a mtSNP associated with reduced PD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Transport Complex I
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Proteins

Share to Neurons

Share to Parkinson Disease

Share to Peptides

Share to Protective Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 38167865
DOI: 10.1038/s41380-023-02344-0
PMCID: PMC11116102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease.PMID 38167865Read ↗

Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degenerationSemantic proximity Read ↗

The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson’s diseaseSemantic proximity Read ↗

The Landscape of <i>Parkin</i> Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson’s DiseaseSemantic proximity Read ↗

Mitochondrial-derived Peptides: Are They Actually Important?Semantic proximity Read ↗

Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6Semantic proximity Read ↗

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markersSemantic proximity Read ↗

CHCHD2 links mitochondrial dysfunction and α-synuclein misfolding in Parkinson's disease.Semantic proximity Read ↗

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson diseaseSemantic proximity Read ↗

MENTSH: A novel mitochondrial microprotein linked to a SNP associated with type 2 diabetes.Semantic proximity Read ↗

Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease.Semantic proximity Read ↗

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.Semantic proximity Read ↗

Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.