Article
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
The Tohoku journal of experimental medicine - 1 Dec 2010
Su Ning, Xu Xin-Yun, Chen Han, Gao Wen-Chao, Ruan Can-Ping, Wang Qiang, Sun Yan-Ping
Abstract excerpt
The activation of K-ras gene and expression of annexin A1 play an important role in colorectal tumorigenesis. We initiated this study to analyze the possible relationship between the annexin A1 expression and the K-ras mutation status in colorectal cancer. K-ras mutations are present in one fourth to one half of colorectal cancers. Annexin A1, a 37-kDa calcium- and phospholipid-binding protein, is over-expressed...
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