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Article

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

16 Jan 2016

Abstract excerpt

Human platelets contain microRNAs (miRNAs) and miRNA processing machinery, but their contribution to platelet function remains incompletely understood. Here, we show that murine megakaryocyte (MK)-specific knockdown of Dicer1, the ribonuclease that cleaves miRNA precursors into mature miRNAs, reduces the level of the majority of miRNAs in platelets. This leads to altered platelet messenger RNA (mRNA) expression...

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PMID: 26773046
DOI: 10.1182/blood-2015-07-661371

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