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Article

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.

European journal of human genetics : EJHG - 1 Sept 2008

Wermter Anne-Kathrin, Scherag André, Meyre David, Reichwald Kathrin, Durand Emmanuelle, Nguyen Thuy Trang, Koberwitz Kerstin, Lichtner Peter, Meitinger Thomas, Schäfer Helmut, Hinney Anke, Froguel Philippe, Hebebrand Johannes, Brönner Günter

Abstract excerpt

DLK1 is part of the Notch signalling pathway that controls various developmental processes. A functional role for DLK1 in adipogenesis is suggested by several animal models. Interestingly, the DLK1 gene is imprinted in eutherian mammals. To study whether variations in DLK1 affect body weight in humans, we analysed 32 polymorphisms in a 109 kb genomic region encompassing DLK1 on human chromosome 14. In a study...

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Identifiers

PMID: 18398438
DOI: 10.1038/ejhg.2008.64

Genes

DLK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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