Article
Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.
Genome research - 1 Oct 2002
Freking Brad A, Murphy Susan K, Wylie Andrew A, Rhodes Simon J, Keele John W, Leymaster Kreg A, Jirtle Randy L, Smith Timothy P L
Abstract excerpt
A small genetic region near the telomere of ovine chromosome 18 was previously shown to carry the mutation causing the callipyge muscle hypertrophy phenotype in sheep. Expression of this phenotype is the only known case in mammals of paternal polar overdominance gene action. A region surrounding two positional candidate genes was sequenced in animals of known genotype. Mutation detection focused on an inbred ram...
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