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Article

The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.

Nature genetics - 1 Apr 2001

Charlier C, Segers K, Karim L, Shay T, Gyapay G, Cockett N, Georges M

Abstract excerpt

The callipyge (CLPG) phenotype (from kappa(alpha)lambda(iota), "beautiful," and pi(iota)gamma(epsilon), "buttocks") described in sheep is an inherited muscular hypertrophy that is subject to an unusual parent-of-origin effect referred to as polar overdominance: only heterozygous individuals havin...

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Source

Identifiers

PMID: 11279514
DOI: 10.1038/86856

Genes

DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11279514-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.PMID 11279514Read ↗

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.Semantic proximity Read ↗

Expression of PEG11 and PEG11AS transcripts in normal and callipyge sheep.Semantic proximity Read ↗

Towards the molecular understanding of the polar overdominance phenomenon associated with the callipyge phenotype in sheep.Semantic proximity Read ↗

The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcription in cis.Semantic proximity Read ↗

New insights into polar overdominance in callipyge sheep.Semantic proximity Read ↗

Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.Semantic proximity Read ↗

The ovine callipyge locus: a paradigm illustrating the importance of non-Mendelian genetics in livestock.Semantic proximity Read ↗

Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs.Semantic proximity Read ↗

Assessing the effect of the CLPG mutation on the microRNA catalog of skeletal muscle using high-throughput sequencing.Semantic proximity Read ↗

BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.Semantic proximity Read ↗

Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs.Semantic proximity Read ↗

Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.Semantic proximity Read ↗

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