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Article

Towards the molecular understanding of the polar overdominance phenomenon associated with the callipyge phenotype in sheep.

Bulletin et memoires de l'Academie royale de medecine de Belgique - 1 Jan 2004

Charlier C

Abstract excerpt

Most medically or agronomically important phenotypes are "complex" inherited traits. They are influenced by genes but not transmitted according to Mendel's laws. Recently, Steve Henikoff wrote: "The nature of quantitative-trait variation is one of the last unexplored frontiers in genetics, awaiting the future and definitive identification of complex trait determinants, wether they be genetic or epigenetic"...

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Source

Identifiers

PMID: 16035622

Genes

DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Towards the molecular understanding of the polar overdominance phenomenon associated with the callipyge phenotype in sheep.PMID 16035622Read ↗

The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.Semantic proximity Read ↗

The ovine callipyge locus: a paradigm illustrating the importance of non-Mendelian genetics in livestock.Semantic proximity Read ↗

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.Semantic proximity Read ↗

New insights into polar overdominance in callipyge sheep.Semantic proximity Read ↗

Polar overdominance at the ovine callipyge locus.Semantic proximity Read ↗

Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.Semantic proximity Read ↗

Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs.Semantic proximity Read ↗

Assessing the effect of the CLPG mutation on the microRNA catalog of skeletal muscle using high-throughput sequencing.Semantic proximity Read ↗

Expression of PEG11 and PEG11AS transcripts in normal and callipyge sheep.Semantic proximity Read ↗

Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs.Semantic proximity Read ↗

Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.Semantic proximity Read ↗

Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.Semantic proximity Read ↗

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