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Article

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.

Current biology : CB - 26 Oct 2004

Davis Erica, Jensen Charlotte Harken, Schroder Henrik Daa, Farnir Frédéric, Shay-Hadfield Tracy, Kliem Anette, Cockett Noelle, Georges Michel, Charlier Carole

Abstract excerpt

The callipyge (CLPG) phenotype is an inherited skeletal muscle hypertrophy described in sheep. It is characterized by an unusual mode of inheritance ("polar overdominance") in which only heterozygous individuals having received the CLPG mutation from their father (+(MAT)/CLPG(PAT)) express the phenotype . +(MAT)/CLPG(PAT) individuals are born normal and develop the muscular hypertrophy at approximately 1 month of...

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Source

Identifiers

PMID: 15498495
DOI: 10.1016/j.cub.2004.09.079

Genes

DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.PMID 15498495Read ↗

Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.Semantic proximity Read ↗

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The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.Semantic proximity Read ↗

Assessing the effect of the CLPG mutation on the microRNA catalog of skeletal muscle using high-throughput sequencing.Semantic proximity Read ↗

Towards the molecular understanding of the polar overdominance phenomenon associated with the callipyge phenotype in sheep.Semantic proximity Read ↗

Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells.Semantic proximity Read ↗

The Imprinted Retrotransposon-Like Gene PEG11 (RTL1) Is Expressed as a Full-Length Protein in Skeletal Muscle from Callipyge SheepSemantic proximity Read ↗

BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.Semantic proximity Read ↗

Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.Semantic proximity Read ↗

Postnatal changes in the expression of genes located in the callipyge region in sheep skeletal muscle.Semantic proximity Read ↗

Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs.Semantic proximity Read ↗

The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcription in cis.Semantic proximity Read ↗

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