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Article

Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2004

Kim Kwan-Suk, Kim Jong-Joo, Dekkers Jack C M, Rothschild Max F

Abstract excerpt

The polar overdominance model of inheritance was proposed to explain the non-Mendelian expression of callipyge muscular hypertrophy in sheep. The callipyge locus (CLPG) maps to the distal portion of ovine Chromosome 18 within the DLK1- GTL2 region and corresponds to human Chromosome 14q32, where uniparental disomy (UPD) of the region is associated with multiple congenital anomalies, including growth retardation...

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Source

Identifiers

PMID: 15366375
DOI: 10.1007/s00335-004-2341-0

Genes

DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs.PMID 15366375Read ↗

The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.Semantic proximity Read ↗

Molecular characteristics of the porcine DLK1 and MEG3 genes.Semantic proximity Read ↗

Towards the molecular understanding of the polar overdominance phenomenon associated with the callipyge phenotype in sheep.Semantic proximity Read ↗

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.Semantic proximity Read ↗

Detection of a quantitative trait locus for ham weight with polar overdominance near the ortholog of the callipyge locus in an experimental pig F2 population.Semantic proximity Read ↗

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.Semantic proximity Read ↗

The ovine callipyge locus: a paradigm illustrating the importance of non-Mendelian genetics in livestock.Semantic proximity Read ↗

Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.Semantic proximity Read ↗

Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.Semantic proximity Read ↗

Polar overdominance at the ovine callipyge locus.Semantic proximity Read ↗

New insights into polar overdominance in callipyge sheep.Semantic proximity Read ↗

Expression of PEG11 and PEG11AS transcripts in normal and callipyge sheep.Semantic proximity Read ↗

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