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Article

New insights into polar overdominance in callipyge sheep.

Animal genetics - 1 Aug 2014

Bidwell C A, Waddell J N, Taxis T M, Yu H, Tellam R L, Neary M K, Cockett N E

Abstract excerpt

The callipyge phenotype in sheep involves substantial postnatal muscle hypertrophy and other changes to carcass composition. A single nucleotide polymorphism in the DLK1-DIO3 imprinted gene cluster alters gene expression of the paternal allele-specific protein-coding genes and several maternal allele-specific long noncoding RNA and microRNA when the mutation is inherited in cis. The inheritance pattern of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24990181
DOI: 10.1111/age.12132

Genes

DIO3
DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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New insights into polar overdominance in callipyge sheep.PMID 24990181Read ↗

Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs.Semantic proximity Read ↗

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The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.Semantic proximity Read ↗

Towards the molecular understanding of the polar overdominance phenomenon associated with the callipyge phenotype in sheep.Semantic proximity Read ↗

Postnatal changes in the expression of genes located in the callipyge region in sheep skeletal muscle.Semantic proximity Read ↗

Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells.Semantic proximity Read ↗

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.Semantic proximity Read ↗

Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.Semantic proximity Read ↗

Differential expression of the GTL2 gene within the callipyge region of ovine chromosome 18.Semantic proximity Read ↗

Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.Semantic proximity Read ↗

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Analysis of gene expression during the onset of muscle hypertrophy in callipyge lambs.Semantic proximity Read ↗

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