Polymorphisms in<i>RAD51, XRCC2</i>, and<i>XRCC3</i>Are Not Related to Breast Cancer Risk

Abstract excerpt

Highly penetrant, but rare, mutations in genes involved in double-strand break repair (i.e., BRCA1 and BRCA2) are associated with a risk for breast cancer of 40% to 65% by age 70 years (1, 2). Polymorphisms in other double-strand break repair genes are thought to contribute to the risk for the disease, either independently or through modifying the risk associated with rare mutations.This study focuses on...

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