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Article

Variants in DNA double-strand break repair genes and risk of familial breast cancer in a South American population.

Breast cancer research and treatment - 1 Aug 2010

Jara Lilian, Dubois Karen, Gaete Daniel, de Mayo Tomas, Ratkevicius Nikalai, Bravo Teresa, Margarit Sonia, Blanco Rafael, Gómez Fernando, Waugh Enrique, Peralta Octavio, Reyes Jose M, Ibáñez Gladys, González-Hormazábal Patricio

Abstract excerpt

The double-strand break (DSB) DNA repair pathway has been implicated in breast cancer (BC). RAD51 and its paralogs XRCC3 and RAD51D play an important role in the repair of DSB through homologous recombination (HR). Some polymorphisms including XRCC3-Thr241Met, RAD51-135G>C, and RAD51D-E233G have been found to confer increased BC susceptibility. In order to detect novel mutations that may contribute to BC...

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Source

Identifiers

PMID: 20054644
DOI: 10.1007/s10549-009-0709-2

Genes

XRCC3
RAD51
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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