Article
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.
American journal of human genetics - 1 Dec 2007
Antoniou Antonis C, Sinilnikova Olga M, Simard Jacques, Léoné Mélanie, Dumont Martine, Neuhausen Susan L, Struewing Jeffery P, Stoppa-Lyonnet Dominique, Barjhoux Laure, Hughes David J, Coupier Isabelle, Belotti Muriel, Lasset Christine, Bonadona Valérie, Bignon Yves-Jean, Rebbeck Timothy R, Wagner Theresa, Lynch Henry T, Domchek Susan M, Nathanson Katherine L, Garber Judy E, Weitzel Jeffrey, Narod Steven A, Tomlinson Gail, Olopade Olufunmilayo I, Godwin Andrew, Isaacs Claudine, Jakubowska Anna, Lubinski Jan, Gronwald Jacek, Górski Bohdan, Byrski Tomasz, Huzarski Tomasz, Peock Susan, Cook Margaret, Baynes Caroline, Murray Alexandra, Rogers Mark, Daly Peter A, Dorkins Huw, Schmutzler Rita K, Versmold Beatrix, Engel Christoph, Meindl Alfons, Arnold Norbert, Niederacher Dieter, Deissler Helmut, Spurdle Amanda B, Chen Xiaoqing, Waddell Nicola, Cloonan Nicole, Kirchhoff Tomas, Offit Kenneth, Friedman Eitan, Kaufmann Bella, Laitman Yael, Galore Gilli, Rennert Gad, Lejbkowicz Flavio, Raskin Leon, Andrulis Irene L, Ilyushik Eduard, Ozcelik Hilmi, Devilee Peter, Vreeswijk Maaike P G, Greene Mark H, Prindiville Sheila A, Osorio Ana, Benitez Javier, Zikan Michal, Szabo Csilla I, Kilpivaara Outi, Nevanlinna Heli, Hamann Ute, Durocher Francine, Arason Adalgeir, Couch Fergus J, Easton Douglas F, Chenevix-Trench Georgia
Abstract excerpt
RAD51 is an important component of double-stranded DNA-repair mechanisms that interacts with both BRCA1 and BRCA2. A single-nucleotide polymorphism (SNP) in the 5' untranslated region (UTR) of RAD51, 135G-->C, has been suggested as a possible modifier of breast cancer risk in BRCA1 and BRCA2 mutation carriers. We pooled genotype data for 8,512 female mutation carriers from 19 studies for the RAD51 135G-->C SNP....
Read the complete abstract on PubMed