Article
Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2005
Webb Penelope M, Hopper John L, Newman Beth, Chen Xiaoqing, Kelemen Livia, Giles Graham G, Southey Melissa C, Chenevix-Trench Georgia, Spurdle Amanda B
Abstract excerpt
Deficiencies in DNA repair have been hypothesized to increase cancer risk and excess cancer incidence is a feature of inherited diseases caused by defects in DNA damage recognition and repair. We investigated, using a case-control design, whether the double-strand break repair gene polymorphisms RAD51 5' untranslated region -135 G > C, XRCC2 R188H G > A, and XRCC3 T241M C > T were associated with risk of breast...
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