Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.

doi:10.1016/j.canep.2009.11.002

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Article

Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.

Cancer epidemiology - 1 Feb 2010

Silva Susana N, Tomar Marta, Paulo Claudia, Gomes Bruno Costa, Azevedo Ana Paula, Teixeira Valdemar, Pina Julieta Esperança, Rueff José, Gaspar Jorge Francisco

Abstract excerpt

The possible role for DNA repair deficiencies in cancer development, namely in breast cancer has been the subject of increasing interest since it has been reported that breast cancer patients might be deficient in the repair of DNA damage. Exposure to ionizing radiation has been pointed out as a risk factor for breast cancer, and the type of DNA lesions induced by this carcinogen can be repaired by homologous...

Topics

Adult
Aged
Breast Neoplasms
Cell Cycle Proteins
DNA Fingerprinting
DNA Repair
DNA Repair-Deficiency Disorders
DNA-Binding Proteins
Female
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Humans

Middle Aged

Nuclear Proteins

Polymorphism, Single Nucleotide

Portugal

Rad51 Recombinase

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 20004634
DOI: 10.1016/j.canep.2009.11.002

Genes

XRCC2
XRCC3
RAD51

Variants

rs3218536
rs3218536
rs3218536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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