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Article

The effect of conditional inactivation of beta 1 integrins using twist 2 Cre, Osterix Cre and osteocalcin Cre lines on skeletal phenotype.

Bone - 1 Nov 2014

Shekaran Asha, Shoemaker James T, Kavanaugh Taylor E, Lin Angela S, LaPlaca Michelle C, Fan Yuhong, Guldberg Robert E, García Andrés J

Abstract excerpt

Skeletal development and growth are complex processes regulated by multiple microenvironmental cues, including integrin-ECM interactions. The β1 sub-family of integrins is the largest integrin sub-family and constitutes the main integrin binding partners of collagen I, the major ECM component of bone. As complete β1 integrin knockout results in embryonic lethality, studies of β1 integrin function in vivo rely on...

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Identifiers

PMID: 25183373
DOI: 10.1016/j.bone.2014.08.008
PMCID: PMC4189988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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