Article
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
Cell - 4 Apr 2008
Dawlaty Meelad M, Malureanu Liviu, Jeganathan Karthik B, Kao Esther, Sustmann Claudio, Tahk Samuel, Shuai Ke, Grosschedl Rudolf, van Deursen Jan M
Abstract excerpt
RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis. However, the biological relevance of RanBP2 and the in vivo targets of its E3 ligase activity are unknown. Here we show that animals with low amounts of RanBP2 develop severe aneuploidy in the absence of overt transport defects. The main chromosome segregation defect in cells from these mice is...
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