Article

The SUMO activating enzyme subunit, SAE2, contributes SUMO protein bias for mitotic fidelity

2022-03-18

Abstract excerpt

Mammalian cells possess three conjugatable SUMO variants: SUMO1 and the largely indistinguishable SUMO2 and SUMO3 (designated SUMO2/3). Some SUMOylated substrates are modified by both SUMO1 and SUMO2/3, while others show biased modifications towards SUMO1 or SUMO2/3. How preferential SUMO protein conjugation is coordinated is poorly understood. Here, we examine a modification of the catalytic component of the huma...

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Literature Corpus work: d3e8e66a-98cf-5153-8491-3c21bb8e9c3b
DOI: 10.1101/2022.03.18.484840

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