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Article

PTEN stabilizes TOP2A and regulates the DNA decatenation.

Scientific reports - 10 Dec 2015

Kang Xi, Song Chang, Du Xiao, Zhang Cong, Liu Yu, Liang Ling, He Jinxue, Lamb Kristy, Shen Wen H, Yin Yuxin

Abstract excerpt

PTEN is a powerful tumor suppressor that antagonizes the cytoplasmic PI3K-AKT pathway and suppresses cellular proliferation. PTEN also plays a role in the maintenance of genomic stability in the nucleus. Here we report that PTEN facilitates DNA decatenation and controls a decatenation checkpoint. Catenations of DNA formed during replication are decatenated by DNA topoisomerase II (TOP2), and this process is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26657567
DOI: 10.1038/srep17873
PMCID: PMC4674714

Genes

PTEN
OTUD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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