Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function.

The Journal of biological chemistry - 30 Dec 2005

Xu Yiru, Tan Li-Jun, Grachtchouk Vladimir, Voorhees John J, Fisher Gary J

Abstract excerpt

Epidermal growth factor receptor (EGFR), the prototypic receptor protein tyrosine kinase, is a major regulator of growth and survival for many epithelial cell types. We report here that receptor-type protein-tyrosine phosphatase-kappa (RPTP-kappa) dephosphorylates EGFR and thereby regulates its function in human keratinocytes. Protein-tyrosine phosphatase (PTP) inhibitors induced EGFR tyrosine phosphorylation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Keratinocytes

Share to Protein Tyrosine Phosphatases

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to RNA, Small Interfering

Share to Tyrosine

Source

Identifiers

PMID: 16263724
DOI: 10.1074/jbc.M507722200

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function.PMID 16263724Read ↗

Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function.Semantic proximity Read ↗

Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor familySemantic proximity Read ↗

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.Semantic proximity Read ↗

Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future ResearchSemantic proximity Read ↗

The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.Semantic proximity Read ↗

Magnitude of Ubiquitination Determines the Fate of Epidermal Growth Factor Receptor Upon Ligand Stimulation.Semantic proximity Read ↗

Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer.Semantic proximity Read ↗

Disrupting the Transmembrane Domain Oligomerization of Protein Tyrosine Phosphatase Receptor J Promotes its Activity in Cancer CellsSemantic proximity Read ↗

PTPα-mediated Src activation by EGF in human breast cancer cells.Semantic proximity Read ↗

Neu-mediated phosphorylation of protein tyrosine phosphatase epsilon is critical for activation of Src in mammary tumor cells.Semantic proximity Read ↗

The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen.Semantic proximity Read ↗

The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.